目的:探讨白细胞介素8(IL-8)水平检测诊断难治性肺炎支原体肺炎的临床价值。方法:选择难治性肺炎支原体肺炎40例为观察组,同期在本院儿科门诊体检健康儿童40例为对照组。采用酶联免疫吸附法(ELISA)测定两组IL-8水平,并比较两组IL-8水平的差异。结果:观察组急性期IL-8水平非常显著高于对照组(P<0.01);恢复期与对照组比较,差异不显著(P>0.05)。结论:IL-8水平检测对难治性肺炎支原体肺炎具有较高的临床诊断和预测价值。 Objective: To investigate the clinical value of detecting interleukin-8 (IL-8) in the diagnosis of refractory Mycoplasma pneumoniae pneumonia. Methods: 40 cases of refractory Mycoplasma pneumoniae pneumonia were selected as the observation group, 40 cases of healthy children in our pediatric outpatient during the same period as the control group. The levels of IL-8 in the two groups were measured by enzyme-linked immunosorbent assay (ELISA), and the differences of IL-8 levels between the two groups were compared. Results: The level of IL-8 in acute phase of the observation group was significantly higher than that of the control group (P <0.01). There was no significant difference between the recovery group and the control group (P> 0.05). Conclusion: The detection of IL-8 has a high value in clinical diagnosis and prognosis of refractory Mycoplasma pneumoniae pneumonia.