论文部分内容阅读
本试验以甲状腺组织学、酶活性组织化学及甲状腺功能等检查为主要指标,观察了新农药川化018[N、N′—甲撑一双—(2—氨基—5—巯基—13.4—噻二唑,]及其“中间体”(2—氨基—5—巯基1.34—噻二唑)对繁殖试验仔一代第二窝后代的慢性毒性。实验发现,川化018(500PPM)及其“中间体”(250PPM)可使甲状腺组织明显增生,所测酶组织化学指标,除酸性非特异性酯酶正常,乳酸脱氢酶、琥珀酸脱氢酶、单胺氧化酶、过氧化物酶、乙酰胆碱酯酶,葡萄糖—6—磷酸酶,酸性磷酸酶等都出现不同程度活性增高。而川化018低剂量组(5PPM)与正常对照组未见差异。
In this study, thyroid histology, enzymatic histochemistry and thyroid function tests as the main indicators observed the new pesticide Chuanhua 018 [N, N’-methylene-bis- (2-amino-5-mercapto-13.4- And their intermediates (2-amino-5-mercapto 1.34-thiadiazole) were tested for their chronic toxicity to the second litter generation of the breeding experiment.It was found that Chuanhua 018 (500PPM) and its "intermediate (250 PPM) can significantly proliferate the thyroid tissue, the measured enzyme histochemical indicators, in addition to acid non-specific esterase normal, lactate dehydrogenase, succinate dehydrogenase, monoamine oxidase, peroxidase, acetylcholinesterase, glucose- 6-phosphatase, acid phosphatase and so on all showed varying degrees of activity increased, while the low-dose group of Sichuan 018 (5PPM) and the normal control group no difference.