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目的分析类风湿关节炎(rheumatoid arthritis,RA)患者并发心血管损害(CVD)的临床特点及相关因素。方法回顾性分析RA患者临床资料122例,分为并发CVD的RA(并发CVD组)62例和未并发CVD的RA(单纯RA组)60例为对照组,进行单因素分析和多因素分析,多因素分析采用Logistic回归。结果并发CVD组中患者发病年龄较小、病程较长,两组差异有统计学意义(P<0.05),在性别比例、年龄、体质量指数(BMI)差异无统计学意义;并发CVD组中常见损害依次为高血压病、高脂血症和冠心病;心脏超声异常以瓣膜返流(61%)最多见;Logistic回归分析提示28个关节疾病活动度(DAS-28)评分、C反应蛋白(CRP)、总胆固醇(TC)和D二聚体水平升高与并发CVD密切相关。结论 CVD为RA患者常见的关节外表现,且表现多样。DAS-28评分、CRP、TC和D二聚体水平升高与RA并发CVD密切相关。
Objective To analyze the clinical characteristics and related factors of cardiovascular injury (CVD) in patients with rheumatoid arthritis (RA). Methods The clinical data of 122 patients with RA were retrospectively analyzed. One hundred and twenty-two patients with RA (concurrent CVD) and 60 patients with RA without concurrent CVD (RA group) were included in this study. The univariate and multivariate analysis were performed. Multivariate analysis using Logistic regression. Results There was no significant difference in gender, age and body mass index (BMI) between CVD group and CVD group (P <0.05) The common lesions were hypertension, hyperlipidemia and coronary heart disease. The most common echocardiographic abnormalities were valvular regurgitation (61%). Logistic regression analysis showed 28 joint disease activity (DAS-28) scores, C-reactive protein (CRP), total cholesterol (TC) and D dimer levels are closely related with concurrent CVD. Conclusions CVD is a common extra-articular manifestation of RA patients with diverse performance. DAS-28 scores, CRP, TC and D dimer levels and RA concurrent CVD is closely related.