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阿尔茨海默病是常见的神经退行性疾病，使患者出现记忆和多种认知能力上的损害，并导致患者最终死亡。大脑内β－淀粉样肽聚集是阿尔茨海默病发病机理的中心事件，而β－淀粉样肽的β片层折叠结构是β－淀粉样肽聚集的基础。β片层阻断肽是一种可以阻止和／或逆转β片层形成的寡肽，被认为是极具前景的治疗阿尔茨海默病药物的方向之一。本文对近年来β片层阻断肽的研究进展做一综述。“,”Alzheimer′s disease ( AD ) is a common neurodegenerative disorder that causes progressive memory and cognitive impairment and ul-timately leads to death of patients.Aggregation of amyloid β-peptide ( Aβ) is a central event in AD pathogenesis, which is based onβ-sheet formation of Aβpeptides.β-Sheet breaker peptides are oligopeptides that can prevent and/or reverse β-sheet formation and thus represent a promising class of candidates for treatment of AD. This review is to summarize the progress of β-Sheet breaker peptides made in the past few decades.