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自由饮用100mg/L MNNG水溶液24周建立大鼠胃癌前病变模型,治疗12周后处死。模型对照组大鼠血清SOD明显低于正常组(P<0.01),而胃粘膜SOD/MDA分别明显低于/高于正常组(P<0.01)。乐胃煎组大鼠胃粘膜、血清SOD较未经任何治疗的模型对照组明显上升(P<0.01),而胃粘膜MDA则显著下降(P<0.01)。乐胃煎组大鼠中、重度异型增生发生率33.33％,无肿瘤发生,明显低于模型对照组(P<0.05)。结果提示自由基参与了实验性胃癌及癌前病变的发生。乐胃煎抗氧化损伤作用可能是其治疗实验性GPL取效的因素之一。
A rat model of gastric precancerous lesions was established by free drinking 100 mg/L MNNG solution for 24 weeks, and was sacrificed after 12 weeks of treatment. The serum SOD in the model control group was significantly lower than that in the normal group (P<0.01), while the SOD/MDA in the gastric mucosa was significantly lower/higher than the normal group (P<0.01). Compared with the model control group without any treatment, SOD of the gastric mucosa and serum in the Leweijian group was significantly increased (P<0.01), while gastric mucosal MDA was significantly decreased (P<0.01). The incidence of moderate-to-severe dysplasia in Leweijian group was 33.33%. No tumor occurred, which was significantly lower than that in the model control group (P<0.05). The results suggest that free radicals are involved in the occurrence of experimental gastric cancer and precancerous lesions. The anti-oxidative damage effect of Lewei Jian may be one of the factors for its therapeutic effect on experimental GPL.