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目的探讨抗心磷脂抗体(ACA)与脑出血早期血肿扩大的关系。方法应用酶联免疫吸附(ELISA)法对101例健康人,271例脑出血患者发病1～3 h内、24、72 h检测ACA水平。结果血肿扩大组ACA阳性率(77.38%)高于无血肿扩大组(43.91%)(P<0.05,P<0.01)。血肿扩大组随着病情加重ACA阳性率逐渐增高,随发病时间的延长ACA阳性率逐渐降低(P<0.05)。结论 ACA与脑出血早期血肿扩大呈正相关,为脑出血早期血肿扩大的机制和脑出血免疫治疗提供新的观点,为临床上筛选脑出血血肿扩大高风险预警提供有效指标。
Objective To investigate the relationship between anti-cardiolipin antibody (ACA) and early hematoma expansion in patients with intracerebral hemorrhage. Methods The serum levels of ACA in 101 healthy individuals and 271 patients with intracerebral hemorrhage within 1 ~ 3 h were detected by enzyme-linked immunosorbent assay (ELISA) method at 24 and 72 h. Results The positive rate of ACA in hematoma enlargement group (77.38%) was higher than that in hematoma enlargement group (43.91%) (P <0.05, P <0.01). The positive rate of ACA gradually increased with the progression of the hematoma enlargement group. The positive rate of ACA gradually decreased with the increase of the onset time (P <0.05). Conclusions There is a positive correlation between ACA and hematoma enlargement in the early stage of ICH, providing a new view for the mechanism of hematoma enlargement and ICH immunotherapy in early stage of ICH, and providing an effective index for clinical screening of high risk early warning of ICH.