目的通过新辅助化疗提高局部乳腺癌的手术切除率的近期和远期疗效并比较两种不同方案新辅助化疗的疗效。方法106例局部晚期乳腺癌患者分为两组,A组采取CMF方案,B组采取CTF方案进行新辅助化疗,观察肿瘤、腋窝淋巴结的变化,为手术切除提供较好的条件。结果新辅助化疗总有效率为64.2%,其中A组有效率为50.0%,B组为78.9%。A、B两组5年生存率和无病生存率(DFS)分别为37.1%、65.5%和25.9%、55.8%。结论新辅助化疗方案对局部晚期乳腺癌的原发肿瘤及腋窝淋巴结转移灶均有效,为根治性手术和保乳手术创造了条件,提高了生存率和无病生存率,CTF方案效果优于CMF方案。 Objective To evaluate the short-term and long-term effects of neoadjuvant chemotherapy on the surgical resection rate of local breast cancer and to compare the efficacy of neoadjuvant chemotherapy with two different regimens. Methods One hundred and sixty patients with locally advanced breast cancer were divided into two groups: group A received CMF; group B received neoadjuvant chemotherapy with CTF; and observed tumor and axillary lymph node changes to provide better conditions for surgical resection. Results The total effective rate of neoadjuvant chemotherapy was 64.2%, of which the effective rate was 50.0% in group A and 78.9% in group B. The 5-year survival and disease-free survival (DFS) of group A and B were 37.1%, 65.5% and 25.9% and 55.8% respectively. Conclusions Neoadjuvant chemotherapy regimen is effective in primary tumor and axillary lymph node metastasis of locally advanced breast cancer, which provides the conditions for radical surgery and breast-conserving surgery and improves the survival rate and disease-free survival rate. The CTF regimen is better than CMF Program.