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目的 探讨洛阳市HBV、HCV和HGV感染与肝癌的关系。方法 收集洛阳市 6 8例肝癌患者和 179例对照的血清 ,应用EIA法检测HBV、HCV和HGV感染指标。结果 HBV感染的六项血清学指标在病例组和对照组的差异有统计学意义 ,抗 -HCV在两组的差异也具有统计学意义 ,而所有研究对象均未检测到抗 -HGV。HBV与HCV合并感染在肝癌的发生中呈简单相加模式。HBsAg、总HBV感染和抗 -HCV分别可以解释洛阳市肝癌病因的 84 .78%、6 1.19%和 6 .2 0 % ,而抗 -HBs阳性则使肝癌发病危险降低 32 .75 %。结论 HBV和HCV感染是洛阳市肝癌的主要危险因素。
Objective To investigate the relationship between HBV, HCV and HGV infection and liver cancer in Luoyang. Methods Serum samples of 68 HCC patients and 179 controls were collected. The indexes of HBV, HCV and HGV infection were detected by EIA. Results The six serological markers of HBV infection had significant difference between the case group and the control group. The difference of anti-HCV in the two groups was also statistically significant, but none of the subjects were detected anti-HGV. HBV and HCV co-infection in the occurrence of liver cancer was a simple additive model. HBsAg, total HBV infection and anti-HCV could explain 84.78%, 6.19% and 6.2% of the causes of liver cancer in Luoyang respectively, while the positive of anti-HBs could reduce the risk of liver cancer by 32.7%. Conclusion HBV and HCV infection are the main risk factors for liver cancer in Luoyang.