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目的探讨神经节苷酯联合纳洛酮治疗新生儿缺氧缺血性脑病的临床疗效。方法选取缺氧缺血性脑病患儿70例作为研究对象,将其随机分为观察组与对照组,每组35例。两组基础治疗相同,对照组予以纳洛酮治疗,观察组予以神经节苷酯联合纳洛酮治疗。比较两组治疗效果及不同时期神经行为测定(NBNA)评分。结果观察组临床疗效优于对照组,差异有统计学意义(P<0.05);两组患儿治疗前NBNA评分比较,差异未见统计学意义(P>0.05);治疗后不同时间段观察组NBNA评分高于对照组,差异有统计学意义(P<0.05)。结论新生儿缺氧缺血性脑病采用神经节苷酯联合纳洛酮治疗效果显著,治疗总有效率明显高于单一用药,利于受损神经功能的修复与重塑,值得临床应用。
Objective To investigate the clinical efficacy of ganglioside combined with naloxone in the treatment of neonatal hypoxic-ischemic encephalopathy. Methods Seventy children with hypoxic-ischemic encephalopathy were selected as study subjects, which were randomly divided into observation group and control group with 35 cases in each group. The same two groups of basic treatment, the control group was treated with naloxone, the observation group was ganglioside combined with naloxone treatment. The therapeutic effects and NBNA scores at different stages were compared between the two groups. Results The clinical curative effect in the observation group was better than that in the control group (P <0.05). There was no significant difference in NBNA score between the two groups before treatment (P> 0.05) NBNA score higher than the control group, the difference was statistically significant (P <0.05). Conclusion Newborns with hypoxic ischemic encephalopathy by ganglioside combined with naloxone treatment effect is significant, the total effective rate was significantly higher than a single medication, which is conducive to the repair and remodeling of impaired nerve function, deserved clinical application.