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重复观测数据是医学研究中常见的数据形式。只有这种资料满足特定的假定条件，才能保证方差分析的有效性，否则，应该进行校正的一元方差分析。本文讨论了球对称系数的估计方法并对应用中的问题进行了分析。
Repeated observations are a common form of data in medical research. Only if this kind of information satisfies certain assumptions can the validity of ANOVA be guaranteed. Otherwise, a one-way ANOVA should be performed. This article discusses the ball symmetry coefficient estimation method and the application of the problem were analyzed.