中晚期原发性肝癌病灶较大,合并肝硬化者多,绝大多数已失去手术机会,肝动脉栓塞疗法对被膜外浸润之肝癌细胞效果不佳,加之在中晚期时常有门脉主干癌栓形成,防碍动脉栓塞的进行,故对中晚期原发性肝癌的治疗,目前仍是棘手的问题。最近我们试用大剂量纯酒精+阿霉素+碘化油局部注射对3例病灶直径均在13cm以上之中晚期肝癌经4～6个月治疗观察,近期效果比较满意。 In the advanced stage of primary liver cancer, the lesions are large, and there are many patients with liver cirrhosis. Most of them have lost the chance of surgery. Hepatic artery embolization therapy has poor effect on infiltrating hepatocellular carcinoma cells. In addition, portal vein cancer thrombi often occurs in the middle and late stages. The formation of the disease is detrimental to the progress of arterial embolism. Therefore, the treatment of advanced primary liver cancer is still a thorny problem. Recently, we tried large doses of pure alcohol + doxorubicin + iodized oil local injection in 3 cases of lesions with a diameter above 13cm in advanced hepatocellular carcinoma after 4 to 6 months of treatment observed, the recent results were satisfactory.