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口腔癌常规采用放射治疗加外科手术,或单纯外科手术的方法。但是对于T_3和T_4的晚期口腔鳞状细胞癌患者来说,局部控制和生存期仍令人失望,即使应用放疗加手术根治的方法,T_3和T_4患者3年生存率仍小于50%。作者提出采用综合化疗加手术根治的方法,认为此法卓有成效。 1981年11月～1985年1月作者经治疗43例晚期口腔鳞状细胞癌患者,均采用综合化疗随后手术根治的方法。男性41例,女性2例,平均年龄48岁,(27～72岁)他们均未接受过事先治疗。原发部位是:口腔底部21例;舌部9例;龈8例;磨牙后三角区3例;腭2例。临床分期参照UICC的TNM分期方法,全部病例给予3个疗程的化疗。化疗方案:第一个疗程:第1
Oral cancer is usually treated with radiation therapy plus surgery or surgery alone. However, for T3 and T4 patients with advanced oral squamous cell carcinoma, local control and survival are still disappointing. Even with the combination of radiotherapy and surgery, the 3-year survival rate of T3 and T4 is still less than 50%. The author proposes to use the method of comprehensive chemotherapy plus radical surgery and believes that this method is effective. From November 1981 to January 1985, the authors treated 43 patients with advanced oral squamous cell carcinoma and adopted the method of comprehensive chemotherapy followed by radical surgery. There were 41 males and 2 females. The average age was 48 years old (27-72 years old). None of them had received prior treatment. The primary sites were: 21 cases of oral cavity bottom; 9 cases of tongue; 8 cases of hernia; 3 cases of triangular posterior molars; The clinical stage was based on the UICC TNM staging method. All cases were given 3 courses of chemotherapy. Chemotherapy Program: First Course: First