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目的:采用磁共振成像(magnetic resonance imaging,MRI)对阿尔茨海默病(Alzheimer’s disease,AD)发病进程中垂体大小有无变化进行初步研究。方法:采集正常对照(normal control,NC)组41例、轻度认知损害(mild cognitive impairment,MCI)组36例、AD组41例共118例受试者颅脑MRI图像,测量每例垂体前后径、宽径、高径、体积、垂体柄长径并进行标化,采用统计学方法进行组间比较。结果:垂体标化前后径MCI组大于NC组(t=3.882,P=0.000)及AD组(t=5.533,P=0.000)。垂体标化体积MCI组大于NC组(t=2.192,P=0.030)及AD组(t=2.223,P=0.028)。垂体标化宽径、标化高径及标化垂体柄长径MCI组与NC组,MCI组与AD组组间无统计学差异(P>0.05)。结论:MCI患者垂体大于正常人及AD患者,推测在AD发病进程中的MCI期可能存在垂体增大。
Objective: To study the change of pituitary size in Alzheimer’s disease (AD) with magnetic resonance imaging (MRI). Methods: Totally 41 cases of normal control (NC), 36 cases of mild cognitive impairment (MCI) and 41 cases of AD (118 cases) Anteroposterior diameter, width, height, volume, pituitary stalk diameter and standardization, using statistical methods for comparison between groups. Results: Pituitary standardized anteroposterior diameter MCI group was higher than NC group (t = 3.882, P = 0.000) and AD group (t = 5.533, P = 0.000). Pituitary standardized volume in MCI group was higher than that in NC group (t = 2.192, P = 0.030) and AD group (t = 2.223, P = 0.028). There was no significant difference between MCI group and MC group, MCI group and AD group (P> 0.05). Conclusion: The pituitary of MCI patients is larger than that of normal subjects and AD patients. It is speculated that there may be an increase of pituitary in MCI during the process of AD.