目的:探讨不同剂量安宫黄体酮治疗子宫内膜单纯型增生的疗效。方法:将子宫内膜单纯型增生的功血患者111例,分两组周期性服用安宫黄体酮。观察组62例,每周期112 mg;对照组49例,每周期80 mg。观察患者月经恢复情况、副反应及子宫内膜病理变化。结果:治疗2疗程后,观察组治愈率为83.9%;对照组治愈率59.6%,两组比较有显著性差异(2χ=6.161,P<0.05)。治疗4疗程后,观察组治愈率为91.9%;对照组治愈率为83.7%;两组比较无显著性差异(2χ=1.10,P>0.05)。结论:周期性服用安宫黄体酮每日同等剂量时,用药量112 mg比80 mg生效快,疗效好,副反应少。 Objective: To investigate the curative effect of different dosages of medroxyprogesterone acetate on endometrial hyperplasia. Methods: 111 cases of endometrial hyperplasia of dysfunctional uterine bleeding, cyclophosphamide was taken in two groups periodically. The observation group of 62 cases, 112 mg per cycle; control group, 49 cases, 80 mg per cycle. Observation of patients with menstruation recovery, side effects and endometrial pathological changes. Results: After 2 courses of treatment, the cure rate of the observation group was 83.9%. The cure rate of the control group was 59.6%. There was a significant difference between the two groups (2χ = 6.161, P <0.05). After 4 courses of treatment, the cure rate was 91.9% in the observation group and 83.7% in the control group. There was no significant difference between the two groups (2χ = 1.10, P> 0.05). CONCLUSION: When taking Cyclodextrins at the same dosage daily, 112 mg dose is more effective than 80 mg with good curative effect and few side effects.