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Thy-1是一功能尚未确定的细胞表面糖蛋白,它大量表达于小鼠胸腺细胞,外周T细胞及神经元细胞,并广泛作为表面标志应用于区分小鼠外周T 细胞及B 细胞。体外研究资料表明,抗Thy-1单抗与Thy-1交联可诱导小鼠T 细盹活化并联合刺激T 细胞增殖及IL_2分泌;抗Thy-1单抗还可导致神经细胞的功能发生变化。
Thy-1 is a functionally indentified cell surface glycoprotein that is abundantly expressed in mouse thymocytes, peripheral T cells and neuronal cells and is widely used as a surface marker to differentiate mouse peripheral T cells and B cells. In vitro data show that anti-Thy-1 monoclonal antibody cross-linked with Thy-1 can induce mouse navel T activation and combined to stimulate T cell proliferation and IL 2 secretion; Anti-Thy-1 monoclonal antibody can also lead to changes in the function of nerve cells .