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目的:观察凉血消癜汤治疗血热型儿童过敏性紫癜(Henoch-schonlein purpura,HSP)的临床疗效。方法:将60例过敏性紫癜患者随机分为2组各30例,治疗组运用凉血消癜汤加西药治疗,对照组口服仙特明片和维生素C。4周为1疗程,所有病例均治疗1疗程,分别于治疗前和治疗后测定T细胞亚群CD3、CD4、CD8、CD4/CD8比值,并评价临床疗效。结果:总有效率治疗组为93.4%,对照组为73.3%,2组比较,差异有统计学意义(P=0.0377<0.05)。随访1年,发现治疗组复发1次及以上者4例,复发率13.3%,对照组复发1次及以上者13例,复发率43.3%,2组比较,差异有统计学意义(χ~2=6.6484,P<0.05)。治疗后,治疗组CD3、CD4及CD8提高较对照组明显,CD4/CD8比值降低较对照组明显,2组比较,差异有统计学意义(P<0.05,P<0.05)。结论:中药能调节HSP患儿的免疫功能,能缩短HSP患儿的症状持续时间,降低HSP患儿的复发率。
Objective: To observe the clinical efficacy of Liangxuehexidei Decoction in the treatment of Henoch-schonlein purpura (HSP) in children with blood-heat syndrome. Methods: Sixty patients with allergic purpura were randomly divided into two groups of 30 cases. The treatment group was treated with Tongxitangxuezhengtang, and the control group received Xiantexue tablets and vitamin C. 4 weeks for a course of treatment, all cases were treated for 1 course of treatment were measured before and after treatment T cell subsets CD3, CD4, CD8, CD4 / CD8 ratio, and evaluate the clinical efficacy. Results: The total effective rate was 93.4% in the treatment group and 73.3% in the control group. There was significant difference between the two groups (P = 0.0377 <0.05). After one year of follow-up, it was found that the recurrence rate was 13.3% in the treatment group with recurrence of 1 or more and 13 cases with the recurrence rate of 1 or more in the control group (43.3%). There was significant difference between the two groups (χ ~ 2 = 6.6484, P <0.05). After treatment, the increase of CD3, CD4 and CD8 of the treatment group was more obvious than that of the control group, and the decrease of CD4 / CD8 ratio was more obvious than the control group. There was significant difference between the two groups (P <0.05, P <0.05). Conclusion: Chinese medicine can regulate the immune function of children with HSP, can shorten the duration of symptoms in children with HSP and reduce the recurrence rate of children with HSP.