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为了解成人用吸附精制白喉破伤风二联类毒素 (成人白破二联 )的人体反应及血清学效果 ,于 1999年 3月在北京市朝阳区5所小学对 2 14名小学一年级学生随机分为两组 ,分别接种北京生物制品研究所 (北京所 )、上海生物制品研究所 (上海所 )生产的成人白破二联。人体反应观察结果显示 :接种北京所疫苗 2 4小时全身中、强反应发生率为 2 2 5 % ,局部反应发生率 <7% ;接种上海所疫苗局部与全身中、强反应发生率均 <7%。用间接血凝法检测免疫前后配对血清白喉、破伤风抗毒素含量显示 :北京所疫苗人群免疫后白喉、破伤风抗体较免疫前≥ 4倍增长率分别为 98 9%、96 6 % ,成功率均为 10 0 0 % ;上海所疫苗人群免疫后白喉、破伤风抗体较免疫前≥ 4倍增长率分别为 93 2 %、98 8% ,成功率分别为 97 7%、10 0 0 %。观察结果表明 ,在小学一年级学生中使用上海所生产的成人白破二联是安全有效的。另外 ,根据本次观察 ,免疫前白喉抗体仍保持在较高水平 ,而破伤风抗体已下降至较低水平 ,提示有必要继续观察小学一年级学生加强免疫后血清白喉抗体消退情况 ,并据此考虑是否取消北京市初中一年级白喉类毒素加强免疫 ,同时将高三、中专、技校毕业班和外地进京大学一年级学生的白喉类毒素加强免疫改为成人白破二联免疫
In order to understand the human response and serological effects of diphtheria tetanus diphtheria toxoid (adult white broken two joint) in adults, in March 1999, 2 14 primary freshmen in 5 primary schools in Chaoyang District, Beijing Divided into two groups, respectively, inoculated Beijing Institute of Biological Products (Beijing Institute), Shanghai Institute of Biological Products (Shanghai Institute) produced by the adult white broken two. The results of human reaction showed that the incidence of local reactions was <2.5% in local vaccines and <7% in local vaccines. The incidence of local and systemic immunizations in vaccinated Shanghai was <7 %. By indirect hemagglutination test before and after pairing serum diphtheria, tetanus antitoxin content: Beijing vaccine population diphtheria, tetanus after immunization than before immunization ≥ 4 times the growth rates were 98 9%, 96 6%, the success rate were Was 10 0%. After immunization, the diphtheria and tetanus antibodies in Shanghai vaccinated population were ≥ 4 times higher than those before immunization. The rates of growth were 93 2% and 98 8% respectively. The success rates were 97 7% and 100 0% respectively. The observation shows that it is safe and effective to use the adult white diuretic combination produced in Shanghai among first-year primary school students. In addition, according to this observation, pre-immune diphtheria antibodies remain at high levels and tetanus antibodies have dropped to low levels, suggesting the need to continue observing the regression of serum diphtheria antibodies after first-grade primary school immunization. To consider whether to abolish the first-grade diphtheria toxoid-boosting in junior high school in Beijing and to strengthen the immunization against diphtheria toxoid in first year students from third year, secondary school, technical school graduates and freshmen from Peking University