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在火力发电厂下风侧居民区内收集大气颗粒物，经二氯甲烷提取，减压浓缩，橄榄油溶解作为受试物。给小鼠ｉｐ不同浓度受试物，观察精子畸形率，睾丸染色体畸变率和早期精细胞微核率的变化，以评价提取物对雄鼠生殖细胞的遗传毒效应。结果表明：５ｍｌ／ｋｇ抽取物对雄鼠生殖细胞无明显诱变性；１０ｍｇ／ｋｇ以上可诱发精子畸形率显著高于阴性对照；２５ｍｇ／ｋｇ以上提取物可使精原细胞和初级精母细胞染色体畸变率明显升高，早期精细胞微核率增加。实验结果表明大气飘尘的有机提取物可透过血睾屏障进入雄性生殖细胞，诱发遗传物质突变。
Atmospheric particulate matter was collected in the residential area on the windward side of the thermal power plant, extracted with methylene chloride, concentrated under reduced pressure and dissolved in olive oil as the test substance. To mice ip different concentrations of the test substance, observation of sperm abnormality rate, testicular chromosome aberration rate and early sperm micronucleus frequency changes to evaluate the extract on the male rat germ cell genotoxic effect. The results showed that: 5ml / kg extract had no obvious mutagenicity on male germ cells; 10mg / kg or more induced sperm deformity rate was significantly higher than the negative control; 25mg / kg extract can spermatogonia and primary spermatocytes Chromosome aberration rate was significantly increased early micronucleus rate of sperm cells increased. The experimental results show that atmospheric airborne organic extract can enter the male germ cells through the blood-testis barrier and induce mutations of genetic material.