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目的：研究大黄虫丸防治肝纤维化的作用。方法：运用大鼠免疫性肝纤维化模型，观察大黄虫丸对肝组织病理学、肝羟脯氨酸（ＨＹＰ）含量的影响。结果：大黄虫丸预防和治疗试验肝纤维化率分别为７２．７％和７１．２％，而模型组和秋水仙碱组肝纤维化率为９２．３％～１００％，尤其是大黄虫丸治疗试验组肝ＨＹＰ含量下降显著，与模型组比较Ｐ＜０．０５。结论：大黄虫丸有一定的抗肝纤维化作用，尤其适用于对肝纤维组织的降解
Objective: To study the effect of Dahuangqichong Pill on liver fibrosis. METHODS: The rat model of immune fibrosis was used to observe the effects of Dahuangqichong Pills on liver histopathology and hepatic hydroxyproline (HYP) content. Results: The rate of hepatic fibrosis in the prevention and treatment of Dahuangqichong Pills was 72.7% and 71.2%, respectively, while the hepatic fibrosis rate in the model group and colchicine group was 92.3% to 100%, especially Rhubarb. The liver HYP content in the test group had a significant decrease, and P<0.05 compared with the model group. Conclusion: Rhubarb has a certain anti-hepatic fibrosis effect, especially suitable for the degradation of liver fibrous tissue