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目的探讨欣普贝生(地诺前列酮栓)用于足月妊娠胎膜早破引产的临床效果。方法选择有引产特征的单胎头位初产妇120例,随机分为研究组和对照组各60例,研究组经阴道后穹窿放置欣普贝生10mg,对照组给予催产素静脉滴注引产,比较其临床效果及药物对母婴安全性影响。结果研究组和对照组引产成功率分别为80.8%和58.3%、平均临产时间分别为(8.5±3.5)h和(49.6±16.6)h、总产程分别为(8.2±1.9)h和(19.9±5.6)h、剖宫产率分别为15.0%和40.0%、产后出血量分别为(158.7±28.9)ml和(158.7±28.9)ml,两组比较,差异有统计学意义(P<0.01);研究组和对照组羊水污染率分别为5%和30%,差异有统计学意义(P<0.001)。两组新生儿窒息发生情况差别无统计学意义;欣普贝生引发宫缩过强、胎心率增快发生率较催产素组高。结论欣普贝生用于足月妊娠引产安全可行、效果较好,但有诱发宫缩过强、胎心率增快的副反应,用药后应严密监测宫缩、产程及胎心,必要时取出栓剂。
Objective To investigate the clinical effect of tinprostone (dinoprostone suppository) for term pregnancy induced premature rupture of membranes. Methods A total of 120 primiparous women with induced abortion were randomly divided into study group (60 cases) and control group (60 cases). In the study group, 10 mg of Xinpibisheng was placed in the vaginal fornix. The control group was given intravenous drip of oxytocin, Compare the clinical effect and the influence of drugs on the safety of mother and infant. Results The success rates of induction of labor in study group and control group were 80.8% and 58.3%, the average duration of labor was (8.5 ± 3.5) h and (49.6 ± 16.6) h respectively, the total duration of labor was (8.2 ± 1.9) h and (19.9 ± 5.6) h, the rate of cesarean section was 15.0% and 40.0% respectively, and the amount of postpartum hemorrhage were (158.7 ± 28.9) ml and (158.7 ± 28.9) ml respectively. There was significant difference between the two groups (P <0.01). Amniotic fluid contamination rates in the study and control groups were 5% and 30%, respectively, with significant differences (P <0.001). There was no significant difference in the incidence of neonatal asphyxia between the two groups; Entropubine caused too much contractions, and the incidence of fetal heart rate increased faster than oxytocin group. Conclusions: Thinprofen is safe and feasible for induced abortion in full-term pregnancy and has good effect. However, side effects such as excessive contraction of the uterine contractions and increased fetal heart rate can be monitored. Uterine contractions, labor and fetal heart rate should be closely monitored after treatment. Remove the suppository.