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本文用２～５×１０９个幽门螺杆菌临床分离株细菌型与Ｌ型口饲感染了不同种的小鼠（ＫＭ种，Ｃ５７ＢＬ／６Ｎ系），于感染后９０天处死小鼠。组织学检查表明，口服细菌型与Ｌ型小鼠多数出现胃肠粘膜组织的慢性间质性炎症（１５／１８，２４／３４），表现为淋巴细胞和单核巨噬细胞的浸润，同时引起肝脏细胞的轻微毒性变化。免疫组化技术（ＡＢＣ法）证实，这些病变确由幽门螺杆菌感染引起（ＨＰ抗原检出率１２／１５和１９／２４）。在形态上，两组细菌均主要以圆球体形式在胃粘膜存在和潜伏。提示ＨＰ－Ｌ型仍保留一定的毒力因素，是慢性胃炎、十二指肠溃疡迁延不愈和反复发作的潜在因素，与胃癌的发生发展也有一定的关系。
In this study, 2 to 5 × 109 Helicobacter pylori isolates were infected with different kinds of bacteria (KM strain, C57BL / 6N strain) by bacterial and L-type oral feeding, and mice were killed 90 days after infection. Histological examination showed that chronic oral interstitial inflammation of the gastrointestinal mucosa (15 / 18,24 / 34) occurred in both oral and L-type mice as manifested by infiltration of lymphocytes and mononuclear macrophages, Slight toxic changes in liver cells. Immunohistochemistry (ABC method) confirmed that these lesions are indeed caused by Helicobacter pylori infection (HP antigen detection rate of 12/15 and 19/24). Morphologically, both groups of bacteria mainly exist in the gastric mucosa in the form of spheroids and lurk. Tip HP-L type still retains certain virulence factors, chronic gastritis, duodenal ulcer delayed healing and recurrent potential factors, and the occurrence and development of gastric cancer have a certain relationship.