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目的探讨社区人群中胃食管反流病(GERD)的危险因素及其对生活质量的影响。方法2003年5-9月,采用整群和分层抽样的方法,在广东省内随机选取了广州市(较发达城市)、惠州市(中等发达城市)和惠阳县新圩镇(农村地区)作为调查地区,采用最近衍生出的中文版反流性疾病问卷(RDQ)进行调查。对调查中收集到的GERD症状人群进行危险因素和生活质量的分析。在调查中,每发现1例GERD患者,随后即选取2例健康人作为对照以比较和分析生活质量,生活质量的评估采用SF-36量表。用SPSS10.0作卡方检验、t检验和logistic回归分析等。结果调查中共收集到的GERD症状人群(RDQ评分≥12)83例,并选取166例健康人作为对照。男性患病率高于女性,分别为2.6%和2.4%,但两者差异无统计学意义;65岁以上是相对高发人群(3.5%),但各年龄组GERD的患病率差异亦无统计学意义;体重指数与GERD并无明显的相关性。离婚、分居或丧偶人群(OR4.61)及工作压力大者(OR3.43)倾向于发生GERD。与健康对照组相比,GERD患者的生活质量明显下降。结论心理社会因素在GERD发病中可能起一定的作用,其对患者的生活质量有负面影响。
Objective To explore the risk factors of gastroesophageal reflux disease (GERD) in community population and its impact on quality of life. Methods From May to September in 2003, a cluster and stratified sampling method was used to select randomly selected cities of Guangzhou (more developed cities), Huizhou (medium developed cities) and Xinxu (rural areas) of Huiyang County in Guangdong Province. As a survey area, a survey was conducted using the recently derived Chinese version of the Reflux Disease Questionnaire (RDQ). Analysis of risk factors and quality of life for GERD-affected cohorts collected during the survey. During the survey, 1 case of GERD was found, then 2 healthy people were selected as the control to compare and analyze the quality of life. The quality of life was assessed by the SF-36 scale. Using SPSS10.0 for chi-square test, t test and logistic regression analysis. Results A total of 83 GERD patients (RDQ score ≥12) were collected from the CCP and 166 healthy controls were selected as controls. The prevalence of males was higher than that of females (2.6% and 2.4% respectively), but there was no significant difference between the two groups. The prevalence of GERD in all age groups was also higher than 65% (3.5%) Significance; body mass index and GERD no significant correlation. Divorce, separation or widowhood (OR4.61) and those with high working pressure (OR3.43) tend to develop GERD. Compared with the healthy control group, the quality of life of GERD patients decreased significantly. Conclusion Psychosocial factors may play a role in the pathogenesis of GERD, which has a negative impact on the quality of life of patients.