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目的:探讨针对老年糖尿病早期肾病患者,观察选择Cys C联合β2-MG实施疾病检测与诊断的临床价值。方法:选取我院2012年10月-2014年10月老年糖尿病患者110例。对老年糖尿病患者的UAER(24h尿白蛋白排泄率)进行观察,将所有糖尿病患者分为A1组(糖尿病早期肾病组60例)与A2组(单纯糖尿病组50例)。同期选择健康老年人作为A3组(60例)。针对三组研究对象的Cys C以及β2-MG等指标进行检测,比较各组之间的差异。结果:在血清Cys C以及β2-MG两方面,A1组与A2组分别与A3组患者进行比较,均高于A3组明显(P<0.05);A1组高于A2组糖尿病患者明显(P<0.05);在血清Cr水平方面,A1组、A2组与A3组之间未表现出显著差异(P>0.05)。在Cys C以及β2-MG联合检测最终获得的阳性率方面,A1组高于A2组以及A3组研究对象明显(P<0.05)。结论:针对老年糖尿病早期肾病患者,临床选择Cys C以及β2-MG联合检测的方法,可以有效提高患者临床疾病诊断率,能够有效对老年糖尿病早期肾病进行筛查。
Objective: To investigate the clinical value of detecting and diagnosing Cys C combined with β2-MG in senile diabetic patients with early nephropathy. Methods: 110 cases of elderly diabetic patients in our hospital from October 2012 to October 2014 were selected. The UAER (24h urinary albumin excretion rate) of elderly diabetic patients was observed. All patients with diabetes were divided into A1 group (60 cases of early diabetic nephropathy group) and A2 group (50 cases of simple diabetic group). The same period, select the healthy elderly as the A3 group (60 cases). Cys C and β2-MG and other indicators for the three groups of subjects were tested to compare the differences between the groups. Results: In serum Cys C and β2-MG, the A1 and A2 groups were significantly higher than those in A3 group (P <0.05), while those in A1 group and A2 group were significantly higher than those in A2 group (P < 0.05). There was no significant difference in level of serum Cr between A1, A2 and A3 (P> 0.05). The positive rate of Cys C and β2-MG combined detection was significantly higher in A1 group than in A2 group and in A3 group (P <0.05). CONCLUSIONS: In the elderly with early diabetic nephropathy, the combination of Cys C and β2-MG can effectively improve the diagnosis rate of patients with early-onset diabetic nephropathy.