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组蛋白H3 K27突变的高级别胶质瘤在形态学上相对一致,而H3 G34突变的肿瘤为组织学明显异质性的一组肿瘤,镜下可以是经典的胶质母细胞瘤(GBM),也可以是中枢神经系统原始神经外胚层肿瘤(CNSPNET)。该研究中,作者综合分析了81例G34突变的CNS肿瘤的临床、病理和分子特征等。用常规处理的肿瘤组织进行基因组和表观基因组学研究。尽管组织形态各异,但H3.3 G34突变的CNS肿
Histone H3 K27 mutant high-grade gliomas are relatively morphologically identical, while H3 G34 mutant tumors are a histologically distinct group of tumors that can be histologically glioblastoma (GBM) , Or CNS neuroectodermal tumor (CNSPNET). In this study, the authors comprehensively analyzed the clinical, pathological and molecular features of 81 G34-mutated CNS tumors. Tumor tissues routinely treated for genomic and epigenomic studies. H3.3 G34 mutated CNS swollen despite morphological changes