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We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of(bromoethynyl)benzene with Grignard reagents.The reaction of(bromoethynyl)benzene(1 mmol) with Grignard reagent(1.3 mmol) mediated by NiCl2(4 mol%) and(p-CH3Ph)3P(8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.
We describe a convenient method for the synthesis of 1,2-disubstituted acetylenes via a cross-coupling reaction of (bromoethynyl) benzene with Grignard reagents. The reaction of (bromoethynyl) benzene (1 mmol) with Grignard reagent NiCl2 (4 mol%) and (p-CH3Ph) 3P (8 mol%) in THF could produce 1,2-disubstituted acetylenes in good yields at room temperature.