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目的:通过测定11个不同产地石膏中无机元素含量及对其无机元素进行分析,为建立一种以石膏解热药效为评价指标的质量控制方法提供依据。方法:使用微波消解法对石膏进行快速消解,采用电感耦合等离子体质谱对11个不同产地石膏无机元素进行半定量测定,运用MPP软件对结果进行聚类分析及主成分分析,找出11个不同产地石膏的亲缘关系以及差异元素。对11个不同产地石膏差异元素进行全定量测定,运用MPP软件对结果进行聚类分析,结合半定量测定结果,对11个不同产地石膏的差异元素及亲缘关系进行分析。结果:石膏中含有Na、Mg、Al、K、Ca、V、Cr、Fe(56)、Fe(57)等32种无机元素,产地山东与产地青海的石膏亲缘关系较近,产地江苏与产地四川的石膏相距较近,产地云南与产地安徽的石膏相距较近,11个产地石膏的差异元素为Mg、Al、K、Ca、V、Mn。结论:11个不同产地石膏中无机元素含量有较大的相似度,其差异元素共有6种,6种差异元素之间的差异可以代表不同产地石膏之间的差异,为建立一种以石膏的差异元素判定石膏质量、药效的方法提供了依据。
OBJECTIVE: To provide a basis for the establishment of a quality control method based on gypsum antipyretic efficacy by measuring the content of inorganic elements in 11 different gypsums and analyzing its inorganic elements. Methods: The gypsum was digested rapidly by microwave digestion. The inorganic elements of gypsum in 11 different habitats were semi-quantitatively determined by inductively coupled plasma mass spectrometry. The results of cluster analysis and principal component analysis were analyzed by MPP software to find 11 different Place of origin of gypsum and the relationship between the different elements. The difference element of gypsum in 11 different producing areas was determined quantitatively. The results were clustered by using MPP software, and the difference elements and genetic relationship of gypsum in 11 different producing areas were analyzed with semi-quantitative determination. Results: The gypsum contained 32 inorganic elements such as Na, Mg, Al, K, Ca, V, Cr, Fe (56) and Fe (57). The origin of gypsum was close to that of gypsum in Qinghai, Gypsum in Sichuan is close to each other, and the place of production in Yunnan is relatively close to the gypsum in Anhui Province. The difference elements in 11 gypsums are Mg, Al, K, Ca, V and Mn. CONCLUSION: The content of inorganic elements in gypsum of 11 different habitats has a great similarity, and there are 6 kinds of difference elements. The difference among the 6 kinds of difference elements can represent the difference between gypsum of different producing areas. Difference element to determine the quality of gypsum, pharmacodynamic methods provide the basis.