【同义名】 esophageal achalasia综合征,巨大食管,贲门痉挛,食管无蠕动症,食管扩张运动异常综合征。1884年由Mikulicz首先命名。【病因】食管下段括约肌(LES)功能障碍,使食管下段至贲门口不能松弛而处于持续收缩状态,导致食物通过发生困难。多数学者认为食管下段LES功能障碍与食管植物神经丛发生变性或消失,以及内分泌激素调节功能障碍有关。【临床表现】 20～40岁发病者多见。吞咽梗塞感 [Synonyms] esophageal achalasia syndrome, huge esophageal, cardiac spasm, esophageal peristalsis, esophageal dilatation syndrome. First named in 1884 by Mikulicz. Etiology Lower esophageal sphincter (LES) dysfunction, so that the lower esophagus to the cardia can not relax and in a sustained contraction, resulting in food through the difficulties. Most scholars believe that the lower esophageal LES dysfunction and degeneration or disappearance of the esophageal plexus, and hormonal regulatory dysfunction. Clinical manifestations 20 to 40-year-old incidence of more common. Swallow infarct