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目的 建立利多卡因麻醉致死的动物模型。方法 犬蛛网膜下腔注射利多卡因(37.01mg/kg体重),观察麻醉致死过程的生命体征变化及死后各器官的病理改变特点。结果 实验组犬心电、血压和呼吸消失的平均时间分别为23.8min(7-42min)、16.4min(7-35min)和18.6min(10～47min)。各器官病理改变均呈急死征象。结论 所建模型实验动物的表现和生命体征变化符合蛛网膜下腔麻醉致死的生前表现,可应用于利多卡因麻醉意外致死案件法医学鉴定的实验研究。
Objective To establish an animal model of lethal lidocaine to death. Methods Dogs were injected subcutaneously with lidocaine (37.01mg / kg body weight) to observe the changes of vital signs during anesthesia and the pathological changes of various organs after death. Results The mean time of ECG, blood pressure and respiration in experimental group were 23.8min (7-42min), 16.4min (7-35min) and 18.6min (10-47min), respectively. The pathological changes of various organs showed signs of acute death. Conclusion The performance of model animals and the changes of vital signs are consistent with the life-time manifestations of subarachnoid anesthesia and can be applied to the forensic identification of cases of accidental death of lidocaine.