论文部分内容阅读
目的观察系统性红斑狼疮(SLE)患者外周血狼疮细胞(LEC)形态的变化,探讨其与SLE疾病活动性的关系。方法采用经典改良血块法观察了50例SLE疾病活动期和30例SLE非活动期患者外周血LEC形态,同时与血清自身抗体、补体及SLE疾病活动指数(SLEDAI)对比研究。结果特殊形态的LEC与自身抗体的抗dsDNA抗体和抗核小体抗体(AnuA)(r=0.588,P=0.056;r=0.759,P=0.135),补体C3和C4(r=-0.648,P=0.058;r=-0.589,P=0.057)及SLEDAI(r=0.686,P<0.05)具有明显相关性。SLE活动期组特殊型LEC、自身抗体和补体与SLE非活动期组差异有统计学意义(P<0.01)。当自身抗体和补体与SLEDAI无相关性时,特殊型LEC仍具有良好的相关性(r=0.786,P<0.05)。结论特殊型LEC与自身抗体、补体及SLEDAI有明显的相关性,可作为判断SLE疾病活动性的独特指标。
Objective To observe the changes of peripheral blood lupus cells (LEC) in patients with systemic lupus erythematosus (SLE) and to explore its relationship with the activity of SLE. Methods Fifty patients with active SLE and 30 inactive patients with SLE were enrolled in this study. The morphology of LEC in 50 patients with SLE and 30 SLE inactive patients were observed. The serum autoantibodies, complement and SLE disease activity index (SLEDAI) were also compared. Results The specific forms of anti-dsDNA antibody and anti-nucleosome antibody (AnuA) of LEC and autoantibodies (r = 0.588, P = 0.056; r = 0.759, = 0.058; r = -0.589, P = 0.057) and SLEDAI (r = 0.686, P <0.05). There were significant differences in the special type LEC, autoantibodies and complement between SLE active group and inactive SLE group (P <0.01). Specific autoantibodies and complement did not correlate with SLEDAI (p = 0.05). Conclusion The special type of LEC has significant correlation with autoantibodies, complement and SLEDAI, which can be used as a unique index to judge the activity of SLE disease.