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目的观察多次吡喹酮治疗对抗血吸虫病肝纤维化的作用。方法选择60例血吸虫病肝纤维化患者(临床诊断病例),随机分成治疗组和对照组,每组30人。治疗组在常规护肝、对症治疗的基础上连续3年每年给予吡喹酮60 mg/kg,分2 d服完;对照组予以常规的护肝、对症治疗,2组疗程均为36个月。观察治疗前后2组患者临床症状、肝功能及血清透明质酸(HA)、层粘蛋白(LN)、4型胶原(IV-C)、Ⅲ型前胶原肽(PCIII)等肝纤维化指标的变化,并作统计分析。结果治疗组患者临床症状、肝功能及HA、LN、IV-C、PCIII水平均有不同程度下降,总有效率93%(26/28),对照组总有效率60%(16/27),两组差异有统计学意义(P<0.05)。结论多次吡喹酮治疗对抗血吸虫病肝纤维化有较好的治疗效果。
Objective To observe the effect of multiple praziquantel treatment on liver fibrosis induced by schistosomiasis. Methods 60 cases of schistosomiasis patients with liver fibrosis (clinical diagnosis) were randomly divided into treatment group and control group, with 30 in each group. The patients in the treatment group were treated with praziquantel 60 mg / kg for 2 consecutive days for 3 consecutive years on the basis of conventional liver protection and symptomatic treatment. The patients in the control group were given routine liver protection and symptomatic treatment. The two courses of treatment were 36 months . The clinical symptoms, liver function and the indexes of hepatic fibrosis such as serum hyaluronic acid (HA), laminin (LN), type IV collagen (IV) and type III procollagen peptide (PCIII) were observed before and after treatment Change, and make statistical analysis. Results The clinical symptoms, liver function and the levels of HA, LN, IV-C and PCIII in treatment group decreased to some extent, the total effective rate was 93% (26/28) and the control group was 60% (16/27) The difference between the two groups was statistically significant (P <0.05). Conclusions Multiple praziquantel treatments have a good therapeutic effect on liver fibrosis induced by schistosomiasis.