【摘 要】
：
The natural product,1,7-dimethoxy-2-hydroxyxanthone(1),isolated from Securidaca inappendiculate Hassk,has a potential in the treatment of erectile dysfunction d
【机 构】
：
School of Pharmacy,East China University of Science and Technology,Department of Medicinal Chemistry
【出 处】
：
Chinese Chemical Letters
论文部分内容阅读
The natural product,1,7-dimethoxy-2-hydroxyxanthone(1),isolated from Securidaca inappendiculate Hassk,has a potential in the treatment of erectile dysfunction due to its significant relaxation activity on rabbit Corpus cavernosum.However,the isolation of compound 1 is problematic because of its high similarity in structure to its analogs.In this paper,the first synthesis of 1 was reported featuring two key reactions:a copper-catalyzed coupling reaction and an intramolecular cyclization.
The natural product, 1,7-dimethoxy-2-hydroxyxanthone (1), isolated from Securidaca inappendiculate Hassk, has a potential in the treatment of erectile dysfunction due to its significant relaxation activity on rabbit Corpus cavernosum. Even, the isolation of compound 1 is problematic because of its high similarity in structure to its analogs. In this paper, the first synthesis of 1 was reported featuring two key reactions: a copper-catalyzed coupling reaction and an intramolecular cyclization.
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