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目的探讨妊娠期肝内胆汁淤积症对孕妇妊娠及围生儿结局的影响。方法选择我院2009年9月～2010年10月收治的妊娠期肝内胆汁淤积症患者73例作为观察组,选择同期健康孕妇70例作为对照组,比较两组孕妇妊娠及围生儿结局。结果观察组的早产、剖宫产率分别为12.3%、16.4%,均明显高于对照组的1.4%、4.3%,且观察组产后出血量明显多于对照组,组间差异均有统计学意义(P<0.05);两组胎儿前置胎盘和脐带绕颈发生率间差异无统计学意义(P>0.05),而观察组羊水粪染发生率为15.1%,明显高于对照组的2.9%,组间差异有统计学意义(P<0.05);观察组新生儿窒息、低体重儿的发生率分别为11.0%、19.2%,均明显高于对照组的1.4%、2.9%,且观察组新生儿Apgar评分明显低于对照组,组间差异均有统计学意义(P<0.05)。结论妊娠期肝内胆汁淤积症对孕妇妊娠及围生儿结局均有不良影响,临床应尽早发现并积极治疗,争取获得更好的母婴结局。
Objective To investigate the effect of intrahepatic cholestasis of pregnancy on pregnancy and perinatal outcome of pregnant women. Methods Seventy-three patients with intrahepatic cholestasis of pregnancy admitted from September 2009 to October 2010 in our hospital were selected as the observation group. Seventy healthy pregnant women were selected as the control group. Pregnancy and perinatal outcome were compared between the two groups. Results The rate of preterm delivery and cesarean section in the observation group were 12.3% and 16.4% respectively, which were significantly higher than those in the control group (1.4% and 4.3%, respectively). The postpartum hemorrhage volume in the observation group was significantly more than that in the control group (P <0.05). There was no significant difference in the incidence of prenatal placenta and umbilical cord around neck (P> 0.05), while the incidence of amniotic fluid meningitis in observation group was 15.1%, which was significantly higher than that of control group %, The difference between the groups was statistically significant (P <0.05); the incidence of neonatal asphyxia and low birth weight in observation group were 11.0% and 19.2%, respectively, which were significantly higher than those in control group (1.4% and 2.9%, respectively) Apgar score was significantly lower than the control group, the difference between the two groups were statistically significant (P <0.05). Conclusion Intrahepatic cholestasis of pregnancy has adverse effects on the pregnancy and perinatal outcome of pregnant women. Clinic should find out and treat actively as soon as possible so as to obtain a better maternal and infant outcome.