应用放免方法对48例男性肝硬化患者的基础血清性激素进行测定,检测结果与正常组比较,男性肝硬化患者血清T降低,E_2升高,FSH、LH正常。肝功损害加重,血清T降低,E_2升高愈明显。肝硬化有女性化体征的患者,其血E_2可升高、正常或低于正常。本文资料提示,男性肝硬化患者出现性功能低下、女性化体征,是一个复杂的下丘脑、垂体、睾丸功能异常的结果,与肝损害程度相一致。 Application of radioimmunoassay 48 cases of patients with cirrhosis of the basal serum sex hormones were measured, the test results compared with the normal group, male patients with cirrhosis of serum T decreased, E 2 increased, FSH, LH normal. Liver damage worse, serum T decreased, E 2 increased more obvious. Patients with cirrhosis and feminine signs of E_2 blood can be elevated, normal or below normal. The data suggest that male patients with sexual dysfunction, feminization of liver cirrhosis is a complex hypothalamus, pituitary, testicular dysfunction results consistent with the extent of liver damage.