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一年前在日本发现的经输血传播的病毒(TTV)呈全球性分布。Makto等发现,这一病毒基因组由单链线状DNA组成。他们认为,TTV可能是一种细小病毒,这与其缺乏外膜包裹相一致,但TTV比细小病毒的浮力密度轻得多,基因组也明显较大,而且已证实TTV与已知的同组病毒间无序列同源性。 TTV是否致病已成为目前关注的焦点,但就象庚型肝炎一样,TTV与疾病的关系远未明了。Roman等在TTV致病性的研究中发现,成人慢性肝病患者或HCV感染者的血清标本中,TTV DNA的阳性率为10％～38％,但无统计学意义。有三组研究分别报道,日本供血者中TTV DNA的阳性率为
The transfusion transmitted virus (TTV) found in Japan a year ago was globally distributed. Makto found that the virus genome consists of single-stranded linear DNA. They concluded that TTV may be a parvovirus that is consistent with its lack of outer envelope, but TTV is much lighter than the parvovirus in buoyant density and significantly larger in its genome, and it has been shown that TTV and known viruses of the same group No sequence homology. TTV has become the focus of the current disease, but like hepatitis G, TTV and the relationship between the disease is far from clear. Roman et al. In the study of the pathogenicity of TTV, the positive rate of TTV DNA in serum of adult patients with chronic liver disease or HCV infection was 10% -38%, but it was not statistically significant. There are three groups of studies that reported positive rates of TTV DNA in Japanese blood donors, respectively