半个世纪以前,几乎没有什么降血压药物可供高血压病人选用。当时,只有采取严格的限盐措施,才使部分病人的血压下降。更多的病人即使限盐,血压也不降。五十年代开始出现的降压药只对部分病人有效。而且,用药前不能预测疗效。早期的神经节阻滞药应用后很快发生耐受性,并有广泛的植物神经阻滞作用,带来许多不良的副反应。因此大大限制了它的应用。以后,口服利尿药及一些较适合的 Half a century ago, there was virtually no antihypertensive medication available for hypertensive patients. At that time, only some strict salt restriction measures were taken to lower the blood pressure of some patients. Even more salt in patients, blood pressure does not drop. Antihypertensive drugs that started to appear in the 1950s were only effective in some patients. Moreover, before treatment can not predict efficacy. Early ganglion blockers develop rapidly after application and have extensive autonomic blockade effects resulting in many undesirable side effects. Therefore greatly limits its application. Later, oral diuretics and some more suitable