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目的 比较顺铂水针剂与粉针剂治疗肺癌的疗效和毒性。方法 小细胞肺癌 (SCLC) 67例 ,给予EP方案 ,非小细胞肺癌 (NSCLC) 15 6例 ,给予NP方案化疗。患者被随机纳入顺铂水剂组和粉剂组 ,两组间同类型肺癌所用药物种类、剂量一致。结果 SCLC水剂组与粉剂组的有效率分别为 84.8%与 82 .4%(P>0 .0 5 ) ,NSCLC分别为 3 1.6%与 2 9.9%(P >0 .0 5 )。水剂组与粉剂组毒性反应主要为胃肠道反应和骨髓抑制 ,其中急性恶心呕吐发生率分别为 72 .3 %与 65 .8%(P <0 .0 5 ) ,迟发性恶心呕吐分别为 60 .7%与 5 3 .2 %(P <0 .0 5 ) ;两组间血液毒性及肾毒性无显著性差异。SCLC水剂组与粉剂组平均住院费用分别为 12 468.73元与 92 78.66元 (P <0 .0 5 ) ,NSCLC分别为 172 5 3 .64元与 14 881.72元 (P <0 .0 5 )。结论 顺铂水针剂虽使用方便 ,但疗效较粉针剂无明显提高 ,且胃肠反应更重 ,治疗费用更高 ,临床上应酌情选用
Objective To compare the efficacy and toxicity of Cisplatin injection and powder injection in the treatment of lung cancer. Methods 67 patients with small cell lung cancer (SCLC) were treated with EP regimen and 156 non-small cell lung cancer (NSCLC) patients were given chemotherapy with NP regimen. The patients were randomized to the cisplatin water and powder groups. The same type and dose of drugs were used for the same type of lung cancer between the two groups. Results The effective rates of SCLC water and powder groups were 84.8% and 82.4% (P>0.05), and NSCLC were 3 1.6% and 29.9% respectively (P > 0.05). The toxicity of the water and powder groups was mainly gastrointestinal reactions and myelosuppression. The incidence of acute nausea and vomiting was 72. 3% and 65.8%, respectively (P < 0.05). Delayed nausea and vomiting were observed. It was 60.7% and 53. 2% (P <0.05). There was no significant difference in hematologic toxicity and nephrotoxicity between the two groups. The average hospitalization costs for the SCLC water and powder groups were 12 468.73 yuan and 92 78.66 yuan (P 0.05), respectively, and the NSCLCs were 172 53.64 yuan and 14 881.72 yuan (P 0.05). Conclusion Although cisplatin injection is convenient to use, its efficacy is not significantly improved compared with powder injections, and the gastrointestinal reaction is heavier and the treatment cost is higher. It should be used clinically as appropriate.