病例一:男性,五十七岁,入院前半年,左肩、膝、踝及脚有痛感,踁骨有压痛,手指僵直,体重丧失14公斤。因透视诊断左上叶肺癌而入院。支气管镜检查及组织学均证实为肺癌。患者有眉峯突出,大鼻大颚等巨骨症状,手指及足趾均明显杵状,肝略大,但扫描无肿瘤,肺功能正常,血浆生长激素两次测定各为38及23ng/ml,(正常男人为3.7[±1.7]mg/ml),左上叶肺手术摘除后数日,关节痛及脚痛,以及手指的僵直均消失,血浆生长激素降为3.5ng/ml,唯造骨活动一个月后仍有遗留。已知肿瘤细胞能分泌各种各样的激 Case 1: Male, 57 years old, half a year before admission, with pain in the left shoulder, knee, ankle and foot, tenderness in the cheekbones, stiff fingers, and weight loss of 14 kilograms. He was admitted to the hospital for a perspective diagnosis of lung cancer in the upper left lobe. Bronchoscopy and histology were confirmed as lung cancer. The patients had prominent peaks such as prominent eyebrows, large nose and large scrofula. The fingers and toes were obviously sickle, and the liver was slightly larger. However, no tumors were found in the scan. The lung function was normal. The plasma growth hormone was measured at 38 and 23 ng/ml respectively. (Normal man was 3.7 [±1.7] mg/ml). A few days after the removal of the left upper lobe lung, arthralgia and foot pain, and finger stiffness all disappeared. Plasma growth hormone was reduced to 3.5 ng/ml. One month after the event is still left. Known tumor cells can secrete a variety of