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随着抗结核病化疗的进展,我们对耐药结核病的发生及其危害性有了越来越深刻的认识。耐药结核病产生的第一阶段始于上世纪40年代,链霉素出现并用于临床后,结核分枝杆菌对链霉素很快产生了耐药性,人们因此认识到单一药物治疗结核病的弊端;耐药结核病产生的第二阶段是在上世纪50年代,联合使用对氨基水杨酸和异烟肼治疗结核病,克服了耐药性的产生,并证明坚持用3种药物的方案治疗结核病具有很高的治愈效果。然而,在实际治疗过程中这种观点并没有得到足够的重视,以致逐渐出现结核分枝杆菌对以上3种药,特别是异烟肼的耐药性,成为结核病化疗工作的难题;耐药结核病
With the progress of anti-tuberculosis chemotherapy, we have a more and more profound understanding of the occurrence of drug-resistant TB and its harmfulness. The first phase of drug-resistant TB begins in the 1940s with the emergence of streptomycin and its clinical use. Mycobacterium tuberculosis soon became resistant to streptomycin and people were therefore aware of the shortcomings of single drug treatment of tuberculosis ; The second stage of drug-resistant TB was the combination of aminosalicylic acid and isoniazid in the 1950s that eradicated TB and overcome the emergence of drug resistance and demonstrated adherence to the three-drug regimen for treating tuberculosis with High healing effect. However, in the actual treatment process, this view has not been given sufficient attention, resulting in the gradual emergence of Mycobacterium tuberculosis resistance to these three drugs, especially isoniazid, become a problem of tuberculosis chemotherapy; drug-resistant TB