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目的探讨类风湿关节炎(RA)合并骨质疏松血清骨桥素、TNF-a水平与病情相关性分析。方法选取RA95例,分为3组,RA合并OP患者35例,合并骨量减少30例,无OP患者30例,收集临床资料、实验室指标和疾病情况,对照组20例正常人,ELISA法检测血清骨桥素(SPP1),TNF-α水平,分析与疾病相关性分析。结果血清SPP1、TNF-a水平明显增高,与骨密度T值和发生骨折呈正相关。结论 RA合并OP中,SPP1、TNF-a作为骨代谢指标和炎症指标,可能参与了RA并发OP的发生,临床中指标升高提示了疾病的严重程度。
Objective To investigate the correlation between serum levels of Osteopontin and TNF-a in patients with rheumatoid arthritis (RA) and osteoporosis. Methods RA95 cases were divided into 3 groups, 35 cases with RA combined with OP, 30 cases with osteopenia and 30 cases without OP. The clinical data, laboratory indexes and disease conditions were collected. The control group of 20 normal subjects and ELISA The levels of serum osteopontin (SPP1) and TNF-α were measured and analyzed for disease-relatedness. Results Serum levels of SPP1 and TNF-a were significantly increased, which were positively correlated with T value and fractures. Conclusions SP and TNF-α, as the indicators of bone metabolism and inflammation, may be involved in the pathogenesis of RA complicated with OP in RA combined with OP. Elevated clinical indexes indicate the severity of the disease.