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目的观察肺炎球菌疫苗与流感疫苗联合接种对反复呼吸道感染(recurrent respiratory tract infection,RRTI)患儿健康相关生活质量(health-related quality of life,HRQOL)的影响。方法 278例RRTI患儿随机分为两组,对照组(n=135例)仅使用安慰剂,疫苗接种组(n=143例)联合接种肺炎球菌疫苗与流感疫苗,观察两组患儿相关临床指标以及接种前、接种后14个月、接种后26个月时的PedsQLTM4.0评分。结果两组患儿在例数、性别、年龄、病程及SES评分等方面比较差异无统计学意义(P>0.05);疫苗接种组患儿上、下呼吸道感染次数,呼吸道疾病所致发热次数,抗生素使用天数及总治疗费用均明显少于对照组(P<0.05);两组接种前PedsQLTM4.0评分比较差异无统计学意义(P>0.05),疫苗接种组随接种时间延长,各维度生活质量均明显提高(P<0.05),而对照组差异无统计学意义(P>0.05)。结论肺炎球菌疫苗与流感疫苗联合接种可有效改善RRTI患儿的HRQOL,明显提高PedsQLTM4.0评分,值得临床推广应用。
Objective To observe the effect of combination of pneumococcal vaccine and influenza vaccine on health-related quality of life (HRQOL) in children with recurrent respiratory tract infection (RRTI). Methods 278 patients with RRTI were randomly divided into two groups. The control group (n = 135) received placebo only and the group vaccinated (n = 143) received pneumococcal vaccine and influenza vaccine. Indicators and pre-vaccination, 14 months after vaccination, 26 months after vaccination PedsQLTM4.0 score. Results There was no significant difference in the number of cases, gender, age, course of disease and SES scores between the two groups (P> 0.05). The number of upper and lower respiratory tract infections, the number of fever caused by respiratory diseases, (P <0.05). There was no significant difference in PedsQLTM4.0 score between the two groups before vaccination (P> 0.05). The duration of inoculation of vaccine group was longer (P <0.05), while there was no significant difference in the control group (P> 0.05). Conclusions The combination of pneumococcal vaccine and influenza vaccine can effectively improve HRQOL in children with RRTI, significantly improve the PedsQLTM4.0 score, worthy of clinical application.