论文部分内容阅读
目的：观察脓毒性休克时全身氧供给（ＤＯ２）与氧消耗（ＶＯ２）关系的变化。方法：以改良的盲肠结扎穿孔（ＣＬＰ）方法制备大鼠脓毒性休克模型，观察大鼠休克过程中ＤＯ２、ＶＯ２、氧摄取率（ＥＲＯ２）等变化。结果：ＣＬＰ后５小时已出现平均动脉压明显下降（Ｐ＜０．０５）。在休克早期，ＤＯ２即进行性下降，ＥＲＯ２出现代偿性升高，ＶＯ２维持相对不变，呈非氧供依赖关系；当ＤＯ２降至３４．６０ｍｌ·ｋｇ－１／ｍｉｎ后，ＶＯ２随ＤＯ２线性降低（ｒ＝０．７３３，Ｐ＜０．０１），即呈病理性氧供依赖关系。结论：脓毒性休克时ＤＯ２与ＶＯ２间呈双相变化关系，病理性氧供依赖的出现与组织氧摄取和氧利用功能障碍有关。
Objective: To observe the changes of systemic oxygen supply (DO2) and oxygen consumption (VO2) during septic shock. Methods: The model of septic shock was established by modified cecal ligation and puncture (CLP). The changes of DO2, VO2 and ERO2 during shock were observed. RESULTS: Mean arterial pressure had dropped significantly 5 hours after CLP (P <0.05). In the early stage of shock, DO2 decreased progressively, ERO2 appeared compensatory increase, VO2 remained relatively unchanged, non-oxygen dependency; when DO2 dropped to 34.60ml · kg-1 / min, VO2 with DO2 linear Decreased (r = 0.733, P <0.01), which showed pathological oxygen dependency. Conclusion: There is a biphasic relationship between DO2 and VO2 during septic shock. The occurrence of pathological oxygen dependency may be related to tissue oxygen uptake and oxygen utilization dysfunction.