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[目的]探讨无创机械通气（NPPV）对慢性阻塞性肺疾病（COPD）伴Ⅱ型呼吸衰竭的治疗作用和意义。[方法]对本院60例伴有Ⅱ型呼吸衰竭的COPD患者，在采用基础对症治疗基础上，使用NPPV治疗，观察此方法应用效果以及应用后患者血气分析指标等改善情况。[结果]60例COPD伴Ⅱ型呼吸衰竭患者中，56例成功完成NPPV治疗，人机配合较好，成功率为93．3％（56/60），患者症状均有一定好转；治疗后患者平均心率为（86．7±7．6）次/分钟，呼吸频率为（22．3±2．2）次/分钟，均较治疗前明显改善（P ＜0．05）；治疗后患者pH为（7．39±0．07），更接近正常值，动脉氧分压（PaO2）为（77．8±6．6） mmHg ，较治疗前上升，动脉二氧化碳分压（PaCO2）为（53．5±3．8） mmHg ，较治疗前下降（ P ＜0．05）。[结论]NPPV对患者呼吸功能有显著的改善作用，可纠正呼吸衰竭症状，避免有创通气对患者造成的不良影响。“,”[Objective] To explore the clinical efficacy and significance of noninvasive positive pressure ventila-tion(NPPV) in the treatment of chronic obstructive pulmonary disease(COPD) with type Ⅱ respiratory failure .[Methods] A total of 60 COPD patients with type Ⅱ respiratory failure in our hospital were treated with NPPV based on primary symptomatic treatment .The application efficacy of this method and the improvement of blood gas analysis were observed .[Results] Among 60 COPD patients with type Ⅱ respiratory failure ,56 patients suc-cessfully completed NPPV ,and patients went with the machine well ,and the success rate was 93 .3% (56/60) . Symptoms of patients were improved .After treatment ,the average heart rate of patients was 86 .7 ± 7 .6 and re-spiratory frequency was 22 .3 ± 2 .2 ,which were significantly improved compared with before treatment .After treatment ,pH was 7 .39 ± 0 .07 ,which was more close to the normal value ,and PaO2 was (77 .8 ± 6 .6)mmHg , which was increased compared with before treatment ,and PaCO2 was (53 .5 ± 3 .8)mmHg ,which was decreased compared with before treatment ( P<0 .05) .[Conclusion] NPPV can improve respiratory function of patients ob-viously ,and correct respiratory failure symptoms ,and avoid adverse effects caused by invasive ventilation .