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鼻咽癌的发病不但与地理环境有一定关系而且与不同人群及家族有关系,鼻咽癌与HLA(人体淋巴细胞抗原)相关已有报告。在高发病率的人群中,如在新加坡、马来西亚和中国的鼻咽癌患者中有类似的HLA相关现象。新加坡老年中国人鼻咽癌患者与A2、BW46有关。所有的鼻咽癌患者,与AW19、B17有关,特别是在年青患者这种相关性更明显。在东南亚除了中国人呈高发病率外,少数民族部落仅呈中等发病率。本文调查了45名马来人鼻咽癌患者与HLA的相关性,并以167名正常马来人做对照。结果表明40％(18/45)鼻咽癌患者,其B18频度增加,对照组为13％(22/167)。一种与中国人鼻咽癌有关系的B17频度也增加,为29％(13/45),对照组为11％(18/167)。同中国人鼻咽癌的情况相似。在中国人鼻咽
The incidence of nasopharyngeal carcinoma not only has a certain relationship with the geographical environment and with different groups and families have a relationship between nasopharyngeal carcinoma and HLA (human lymphocyte antigen) has been reported. Among high-prevalence populations, such as NPC in Singapore, Malaysia and China have similar HLA-related phenotypes. Singapore elderly Chinese patients with nasopharyngeal carcinoma and A2, BW46 related. All NPC patients, with AW19, B17 related, especially in young patients with this correlation is more obvious. Except for the high incidence of the Chinese in Southeast Asia, ethnic tribes show only moderate incidence. This study investigated the association of 45 Malays with nasopharyngeal carcinoma with HLA and compared them to 167 normal Malays. The results showed that 40% (18/45) of NPC patients, the frequency of B18 increased in the control group was 13% (22/167). A frequency of B17 associated with nasopharyngeal cancer in Chinese also increased, at 29% (13/45) compared with 11% (18/167) in the control group. Similar to the situation of Chinese people with nasopharyngeal carcinoma. Nasopharyngeal in Chinese