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目的:探讨二甲双胍与克罗米芬治疗多囊卵巢综合征的疗效。方法:随机选取诊断明确的多囊卵巢综合征患者44例,治疗组23例,给予二甲双胍与克罗米芬治疗,对照组21例,只给予克罗米芬治疗。结果:治疗组的排卵率83%和周期妊娠率24%与对照组(89%、17%)比较,差异无统计学意义(P>0.05),治疗组流产率4%与对照组10%比较,差异无统计学意义(P>0.05)。治疗组子宫内膜的厚度显著厚于克罗米芬组(P<0.05)。结论:二甲双胍与克罗米芬治疗多囊卵巢综合征不孕症的疗效尚有待探讨,目前对二甲双胍的适应证存在诸多分歧,但一般认为二甲双胍可作为一种辅助治疗。
Objective: To investigate the curative effect of metformin and clomiphene on polycystic ovary syndrome. Methods: Forty-four patients with polycystic ovary syndrome were randomly selected. Twenty-three patients in the treatment group were treated with metformin and clomiphene citrate, and 21 patients in the control group were treated with clomiphene citrate alone. Results: Compared with the control group (83% vs 17%), 83% ovulation rate and 24% pregnancy rate in the treatment group were not significantly different (P> 0.05). The abortion rate was 4% in the treatment group compared with 10% in the control group , The difference was not statistically significant (P> 0.05). The thickness of the endometrium in the treatment group was significantly thicker than that in the clomiphene citrate group (P <0.05). CONCLUSION: The efficacy of metformin and clomiphene in the treatment of infertility with polycystic ovary syndrome needs to be discussed. There are many differences in the indications of metformin at present. However, metformin is generally considered as an adjuvant therapy.