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目的比较健康志愿者摄入海产品后尿液及唾液中总砷含量随时间的变化情况。方法 4名健康志愿者禁食海产品一周,一次性摄入海苔20 g,收集食用海苔后3 d内尿液及唾液,采用电感耦合-等离子体质谱(ICP-MS)法检测尿液及唾液中总砷含量,尿砷含量以肌酐校正。结果健康志愿者在摄入海苔后,尿总砷含量逐渐上升,在第18小时达到高峰,随后逐渐下降,其中女性达到峰值时间较男性早。唾液总砷含量变化同尿砷变化相似,但达到高峰时间较尿砷提前,在第6小时达到高峰。结论健康人群摄入海产品后,唾液中砷的排除早于尿液,总体变化趋势与尿砷相似,提示唾液砷可以作为一种潜在的砷暴露标志物。
Objective To compare the changes of total arsenic content in urine and saliva of healthy volunteers after consuming marine products over time. Methods Four healthy volunteers fasted the seafood for one week, and took 20 g of seaweed at one time. Urine and saliva were collected within 3 days after eating seaweed. Urine and saliva were detected by inductively coupled plasma-mass spectrometry (ICP-MS) Total arsenic content, urinary arsenic content corrected for creatinine. Results After taking seaweed, healthy volunteers increased the total arsenic content in urine gradually and reached the peak at the 18th hour, then decreased gradually. Among them, women reached the peak earlier than men. The change of total arsenic content in saliva was similar to that of urine arsenic, but reached the peak earlier than that of urine arsenic and peaked at the 6th hour. Conclusion The arsenic excretion in saliva is earlier than that in urine after healthy people ingested. The overall trend is similar to that of urine arsenic, suggesting salivary arsenic may serve as a potential marker of arsenic exposure.