口服缓释给药系统易受胃肠道的生理状态影响 ,药物释放存在着许多易变因素。本研究以生物半衰期短、胃肠道副作用大的非甾体类抗炎药双氯芬酸钠 ( DFS)为模型药物 ,采用无毒、易吸收的天然脱乙酰壳多糖为主要聚合物材料将其制成口服缓释小珠和微粒 ,探讨其体外释药特性 ,为口服 Oral delivery system is susceptible to the physiological state of the gastrointestinal tract, there are many variables drug release. In this study, diclofenac sodium (DFS), a non-steroidal anti-inflammatory drug with short biological half-life and high gastrointestinal side effects, was used as a model drug. Nontoxic and easily absorbed natural chitosan was used as the main polymer material Oral slow release beads and particles to explore its in vitro release characteristics for oral administration