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对口服长效避孕药复方炔雌醚的育龄妇女进行了尿中皮质类固醇及血浆皮质醇浓度的测定,并与正常对照组(103例)作了比较。结果发现54例妇女服药半年后尿中17-OH水平降低,其中28例服药延长到一年时,尿中三类皮质激素(17-OH、17-KS 及17-KGS)浓度均减少。66例曾服复方炔雌醚片2年以上的妇女,尿中三类皮质激素水平亦降低。20例曾短期应用短效避孕药的妇女,血浆皮质醇浓度在正常范围,其中3例服用复方炔雌醚片7～8周期后,皮质醇水平明显升高。本研究提示上述变化可能与复方炔雌醚片对垂体—肾上腺皮质功能及皮质激素代谢酶系的影响有关。
Urinary corticosteroids and plasma cortisol concentrations were determined in women of childbearing age who were oral long-acting contraceptives, compound ethinylestradiol, and compared with the normal control group (n = 103). The results showed that the urinary levels of 17-OH were decreased in 54 women after six months of treatment. The concentrations of the three classes of corticosteroids (17-OH, 17-KS and 17-KGS) in the urine of 28 patients were reduced to one year. Sixty-six women who had taken compound ethinyl-estradiol tablets for more than 2 years also had lower urinary levels of the three classes of corticosteroids. In 20 women who had short-term contraceptives, the plasma cortisol concentration was within the normal range. Cortisol levels were significantly elevated in 3 of the 3 patients taking the compound ethynylestradiol tablets after 7 to 8 cycles. This study suggests that the above changes may be related to compound ethinyl estradiol tablets on pituitary-adrenal function and corticosteroid metabolism enzymes.