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A series of imidazo[1,2-a]pyrimidine derivatives substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized in order to improve their anti-inflammatory activities.Biological tests suggested that these compounds have anti- inflammatory activities with COX-2 selectivity to some extent.
A series of imidazo [1,2-a] pyrimidine derivatives substituted adjacently with two aryls at positions 2 and 3 were designed and synthesized in order to improve their anti-inflammatory activities. Biological facts suggested that these compounds have anti- inflammatory activities with COX -2 selectivity to some extent.