缺血再灌注损伤(I/R)广泛存在于各种创伤与疾病中(如休克、失血、感染、多发性创伤、严重烧伤等)[1],可加重器官、组织的损伤,甚至危及生命。运用中药进行防治并研究其中药防治的机制,对组织器官移植修复和扩大中药应用范围均有着重要的理论意义和临床实践意义。川芎嗪(TMP)是从植物川芎中提取的化合物,近年来有研究发现 Ischemia-reperfusion injury (I / R) is widespread in a variety of trauma and disease (such as shock, blood loss, infection, multiple trauma, severe burns, etc.), can increase the damage of organs and tissues, and even endanger the life . The use of traditional Chinese medicine to prevent and control the mechanism of Chinese medicine prevention and treatment has important theoretical and clinical practical significance for tissue organ transplantation and the expansion of the scope of application of traditional Chinese medicine. Tetramethylpyrazine (TMP) is a compound extracted from the plant Chuanxiong, in recent years, studies have found