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给小鼠背部(L1- S1)贴敷2.73g/kg 的关节康,发现本品可明显抑制复合巴豆油所致的小鼠急性渗出性炎症( P< 0.01)和慢性增生性炎症( P < 0.05);明显加快小鼠耳廓微循环血流速度,改善血流态( P< 0.001),对局部给盐酸肾上腺素10 μg 所造成的微循环障碍有明显的改善作用,微血流恢复正常时间明显短于对照组( P < 0.001);并具有极明显的提高痛阈作用(P< 0.00 1),且能延长小鼠的痛觉潜伏期(P< 0.0 1), 减少疼痛次数(P< 0. 01 ),1 次贴敷镇痛作用可持续4h(P < 0.05)。提示关节康具有明显的消炎镇痛作用和改善微循环障碍作用
The mice’s back (L1-S1) was applied with 2.73 g/kg of joint kang. It was found that this product can significantly inhibit acute exudative inflammation (P<0.01) and chronic proliferative inflammation in mice caused by compound croton oil. Inflammation (P < 0.05); Significantly accelerated blood flow in the microcirculation of the mouse auricle, improved blood flow (P < 0.001), and obvious microcirculatory disturbance caused by local epinephrine hydrochloride 10 μg After the improvement, the restoration time of micro-blood flow was significantly shorter than that of the control group (P < 0.001), and the pain threshold was significantly increased (P < 0.001), and the pain latency of mice was prolonged (P < 0.05). <0.0 1), pain reduction (P <0. 01), and analgesia for 1 application lasted 4 h (P < 0.05). Tip Jiekang has obvious anti-inflammatory and analgesic effects and improves microcirculatory disturbance